The notes will be senior unsecured obligations of the Issuer, and will be fully and unconditionally guaranteed, on a senior unsecured basis, by Ensco. The notes will bear interest at a rate of 3.00% per annum, payable semi-annually on January 31 and July 31 of each year, beginning on July 31, 2017. The notes will be exchangeable into cash, Enscos Class A ordinary shares or a combination of cash and Class A ordinary shares, at Enscos election. The notes will mature on January 31, 2024, unless earlier exchanged, redeemed or repurchased in accordance with their terms prior to such date. Prior to July 31, 2023, the notes will be exchangeable only upon the occurrence of certain events and during certain periods, and thereafter, at any time until the close of business on the business day immediately preceding the maturity date. The initial exchange rate will be 71.3343 Class A ordinary shares per $1,000 principal amount of notes (equivalent to an initial exchange price of approximately $14.02 per Class A ordinary share). The exchange rate will be subject to adjustment in some events but will not be adjusted for accrued and unpaid interest. The notes are being offered and sold to persons reasonably believed to be qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the Securities Act). The offer and sale of the notes, the related guarantee and the Class A ordinary shares issuable upon exchange of the notes have not been, and will not be, registered under the Securities Act or any state securities laws and may not be offered or sold in the United States absent registration or an applicable exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and applicable state laws. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of, or any solicitation of an offer to buy, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. The exchange offers are being made pursuant to an offering memorandum issued in connection with the exchange offers, and this press release is not an offer to purchase any notes in the exchange offers or an offer to sell, or a solicitation of an offer to buy, any of the notes issued in connection with the exchange offers.
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Endometriosis, the presence of uterine tissue outside of the uterus, affects 75% of symptomatic women. Despite the high prevalence, endometriosis is really under-diagnosed, mainly because the only diagnostic method is an invasive one: taking tissue out of the body and examining it. continue reading thisResearchers are on the lookout for new non-invasive diagnostic methods that may reduce time to diagnosis and psychological stress for women and lead to a more personalized treatment. Cancer antigen 125 (CA 125, a protein found on many ovarian cancer cell surfaces) is the most investigated biomarker that may be effective in the diagnosis of endometriosis. http://ajn.me/medicalinterview26570A meta-analysis was published recently in BJOG: An International Journal of Obstetrics and Gynaecology that included 22 studies with 3626 participants. Fourteen studies with 2920 participants were meta-analysed for the sensitivity and specificity of >30 units/ml CA 125 in the diagnosis of endometriosis. Individual study sensitivities ranged from 0% to 87% and specificity from 51% to 100%. The pooled sensitivity of >30 units/ml CA 125 was 52.4%, while the specificity was 92.7%. Furthermore, the sensitivity of CA 125 was higher with a more severe disease. It seems that a positive result means endometriosis, but a negative one might not mean the absence of the disease.
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After passing this exam you shall be certified by the medical board as a qualified and practising gynaecologist. Endometrial Ablation Side Effects Menstruation is a physiological process in women where the inner lining of the uterus, also referred to as endometrium, is shed and replaced with a new one. To relieve the pain, medications, such as antispasmodics, or urinary analgesics may also be prescribed. John Thomson, the Professor of Pathology at the University. Occasional urine leakage or urine leakage while laughing, coughing or sneezing. ✦ Why does my vaginal area itch after sex? There are certain symptoms that help identify this condition sooner. Also, women who may have cancer or tumour in the womb, should avoid this procedure completely. In such cases, it could happen that the cyst may turn into a tumour. Thus, an OB/Lyn is a physician who delivers babies, and treats diseases of the female reproductive organs.