Phase I trials, in addition to moving progress forward for new treatments, also have demonstrated therapeutic success for patients and are well tolerated. Dr. Malek and a team of researchers analyzed data from 2,408 MM patients who participated in 74 phase I clinical trials from 2004-2015 to determine the overall benefit and risks for patients. visit this pageThe analysis indicated that “the therapeutic benefit for patients recruited onto MM phase I trials was significantly higher than that reported for phase I trials of all cancer types.” The team further found that patients’ response rates supported earlier patient entry onto these early phase trials. “Multiple myeloma has seen tremendous progress over the past 12 years with the advent of new agents and survival rates have more than doubled,” says Dr. Malek, Instructor at Case Western Reserve School of Medicine. “However in spite of advancements there still is an unmet need for drug discovery and phase I trials are critical to continued progress. Our research shows that these trials provide therapeutic benefit for patients who participate. Also these new therapies can be more beneficial the earlier patients enroll and no longer need to be thought of as a last resort.” A team of researchers also presented an oral abstract (Abstract #105) finding that obese and older patients with a common form of lymphoma are more likely to develop heart disease following treatment. The researchers conducted a retrospective analysis of more than 400 patients with Diffuse Large B Cell Lymphoma (DLBCL) to determine the incidence of heart failure, heart attack, stroke and other cardiovascular events. They linked patients over age 60 and those with body mass index (BMI) greater than 30 with poorer outcomes and an elevated incidence of cardiovascular events.an ideas breakdown on practical programs in interview technique
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Announces Pricing of its Public Offering of Common Stock MONACO–(Marketwired – Dec 6, 2016) – Safe Bulkers, Inc. (the “Company”) ( NYSE : SB ), an international provider of marine drybulk transportation services, announced today that its public offering of 13,600,000 shares of its Common Stock, par value $0.001 per share (the “Common Stock”), was priced at $1.10 per share. The gross proceeds from the public offering before the underwriting discount and other offering expenses are expected to be approximately $14,960,000.The offering is expected to close on or about December 9, 2016, subject to customary closing conditions. An entity owned and controlled by Polys Hajioannou, the chief executive officer of the Company, will invest in our Common Stock through the purchase of 2,727,272 shares of Common Stock in the public offering. The Company has also granted the underwriters a 30-day option to purchase up to an additional 2,040,000 shares of the Common Stock solely to cover over-allotments, if any. The Company plans to use the net proceeds of the offering for the acquisition of secondhand vessels, capital expenditures and for other general corporate purposes, which may include repayment or settlement of its financial obligations. Stifel, Nicolaus & Company, Incorporated and DNB Markets, Inc. are acting as joint bookrunners of the Public Offering, which is being made under an effective shelf registration statement.Seaport Global Securities LLC is acting as co-manager of the public offering. The public offering is being made only by means of a prospectus supplement and accompanying base prospectus. A preliminary prospectus supplement and accompanying base prospectus relating to the public offering has been filed with the Securities and Exchange Commission (“SEC”) and is available at the SEC’s website at http://www.sec.gov . When available, the final prospectus supplement and accompanying base prospectus relating to the public offering may be obtained from Stifel at One South Street, 15th Floor, Baltimore, MD 21202, Attn: Syndicate Department, telephone: 1-855-300-7136, email: email@example.com or DNB Markets at 200 Park Ave, Floor 31, New York, NY 10166, telephone: 212-681-3800.
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